Manchester Contributes to New Candida Global Guidelines 2025

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Candida species are the leading cause of fungal infections in hospitalized patients, contributing to significant morbidity and mortality.

  • Invasive candidiasis (including candidaemia) primarily affects immunocompromised and critically ill patients.
  • Mucocutaneous candidiasis (e.g., oral thrush, vulvovaginal candidiasis) can affect otherwise healthy individuals but may be recurrent and problematic in those with conditions like diabetes or on immunosuppressants.
  • The rise in antifungal resistance and emerging pathogens such as Candida auris and fluconazole-resistant Candida parapsilosis pose global health risks.
  • Taxonomic changes in Candida classification may cause clinical confusion.
  • Current guidelines are outdated, with limited coverage of new pathogens and treatment strategies.

This review provides updated management recommendations, with detailed evidence summaries available in the appendix.

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